Nils Opel is a Clinician Scientist, Professor for Translational Psychiatry and Senior Consultant at the Department of Psychiatry and Psychotherapy at the University Hospital Jena. He is also Co-Chair of the BMI X-Working Group of the ENIGMA Consortium. Previous positions include a research group leadership at the Institute for Translational Psychiatry, University of Münster and international research collaborations as visiting scholar at the Discipline of Psychiatry, University of Adelaide, Australia. His clinical focus is on treatment-resistant and chronic depression, the interplay between metabolic and affective disorders and research into innovative, personalized diagnostic and treatment approaches for depression. To this end, his methodological focus comprises multimodal neuroimaging techniques, predictive modelling and digital phenotyping methods, such as smartphone-based monitoring of longitudinal disease trajectories.